This study will look at the safety of substituting exenatide for insulin in patients with type 2 diabetes who are currently taking insulin and oral antidiabetic agent(s).
This is an exploratory, multicenter, open-label, 2-arm, parallel trial. Approximately 30 patients with type 2 diabetes, currently on a sulfonylurea, or meglitinide and/or metformin and insulin therapy, will be randomized to discontinue insulin and substitute it with exenatide or remain on their current diabetes therapy regimen. All patients will continue their current diet and exercise regimen during the study.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
49
Research Site
Chula Vista, California, United States
Research Site
Butte, Montana, United States
Research Site
Portland, Oregon, United States
Research Site
Nashville, Tennessee, United States
Research Site
Change in HbA1c (glycosylated hemoglobin) from Baseline to Week 16
Change in HbA1c from Baseline study termination (Week 16)
Time frame: Baseline, Week 16
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San Antonio, Texas, United States