Curcumin in Patients With Mild to Moderate Alzheimer's Disease

Inclusion Criteria: * Male or female at least 50 years old * Diagnosis of probable AD * No history of significant psychiatric or non-AD neurological disease * Proficient in English to be able to perform cognitive testing * Caregiver available to monitor and administer medication and to accompany patient to every clinical visit * On stable doses of cholinesterase inhibitors and memantine (Alzheimer's medications) for 3 months prior to enrollment * On stable doses of all other allowed medications for at least one month prior to starting the study medication Exclusion Criteria: * Current or recent major psychiatric illness (i.e. bipolar disorder, schizophrenia) * Significant, uncontrolled systemic illness (i.e. chronic renal failure, chronic liver disease, poorly controlled diabetes, or poorly controlled congestive heart failure) * Recent history of gastrointestinal bleeding or ulceration * Alcoholism or substance abuse within the past year * Familial, autosomal dominant Alzheimer's disease due to a mutation in a known gene (Presenilin-1, Presenilin-2, or Amyloid Precursor Protein) * NSAIDs (e.g. ibuprofen, naproxen, etc.) taken on a regular basis (more than 3 times per week) * Aspirin at doses more than 325 mg per day * Coumadin, heparin, other anticoagulants * Antioxidants or other supplements including gingko biloba, coenzyme Q10, alpha-lipoic acid * Vitamin E at doses more than 2,000 IU per day * Vitamin C at doses more than 500 mg per day