Assessment of Potential Interactions Between GBR 12909 and Cocaine - 1

National Institute on Drug Abuse (NIDA)24 enrolled

Overview

The purpose of this study is to assess potential interactions between intravenous (IV) cocaine and 3 doses of GBR 12909.

This is Phase 1, double-blind, placebo-controlled human laboratory clinical pharmacology study that will assess the potential interactions between IV cocaine and 3 escalating oral doses of GBR 12909. The primary objective is to determine safety of GBR 12909 administration and if there are significant interactions between GBR 12909 treatment concurrent with IV cocaine infusions.

Study Type

INTERVENTIONAL

Purpose

TREATMENT

Enrollment

Conditions

Cocaine-Related Disorders

Interventions

GBR 12909DRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Must be within 20% ideal body weight and must weigh at least 45 kg. * Must understand the study procedures and provide written informed consent. * Must meet DSM-4 criteria and are non-treatment seeking at time of study. Exclusion Criteria: * Please contact study site for more information

Locations (1)

U of Texas Medical Branch Galveston

Galveston, Texas, United States

Outcomes

Primary Outcomes

Heart rate

Data from ClinicalTrials.gov

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