The purpose of this study is to determine whether levodopa, in combination with a high frequency language training, is effective in boosting naming performance in patients with aphasia.
Our prior work shows that d-amphetamine and the dopamine precursor levodopa markedly improve word learning success in healthy subjects. In this randomized, placebo-controlled, double-blind clinical trial, we probe whether daily administration of levodopa, coupled with several hours of language training every day, will significantly improve naming abilities in patients with aphasia as compared to placebo administration. We furthermore examine with magnetic resonance imaging which brain regions need to be functionally intact for a dopaminergic improvement of language therapy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
12
100mg levodopa per day over 10 days/ treatment phase
Dept. of Neurology, University Hospital Muenster
Münster, North Rhine-Westphalia, Germany
Boost in naming performance (percent correct) through levodopa as compared to placebo
Time frame: immediately after each treatmentphase
Brain activity pattern in successfully trained patients
Time frame: immediately after each treatmentphase
Stability of naming performance after one month and six months post treatment
Time frame: from 1 month untill 6 months after treatment completion
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