Study of DITPA in Patients With Congestive Heart Failure

Inclusion Criteria: * Greater than or equal to 18 years of age * NYHA class III or IV CHF * Females must not be pregnant or lactating. Females of childbearing potential and males must use a reliable means of contraception * Serum total T3 \<= 95 ng/dL with normal levels of TSH * On a regimen consisting of angiotensin-converting enzyme inhibitors and/or angiotensin receptor antagonists, beta blockers, and diuretics for a minimum of 3 months prior to randomization * Clinically stable for 2 weeks prior to randomization (defined as no change in functional class by NYHA, no hospitalization or ER visit, and no intravenous inotropic or vasodilator treatment for 2 weeks) * An LVEF \<= 40%, documented within 6 months prior to randomization, or \> 6 months with confirmation of LVEF by local echocardiographic measurements within 2 weeks prior to randomization * Able to give informed consent Exclusion Criteria: * New onset CHF (less than 3 months prior to randomization) * Active myocarditis, hypertrophic cardiomyopathy, uncorrected primary valvular disease, restrictive cardiomyopathy, uncorrected congenital heart disease, or constrictive pericarditis * Myocardial infarction, unstable ischemic heart disease, stroke, or coronary revascularization procedure within 4 weeks prior to randomization; or an expectation of a coronary revascularization procedure, cardiac transplant, or left ventricular assist device placement being needed within 24 weeks after randomization * History of sudden arrhythmic syncope or sustained ventricular arrhythmia, unless the patient has an implantable cardioverter defibrillator (ICD) for at least 12 weeks prior to randomization; history of clinically significant heart block, unless the patient has had a pacemaker at least 12 weeks prior to randomization * History of cardiac resynchronization therapy in the last 12 weeks prior to randomization or expectation of cardiac resynchronization therapy or ventricular mechanical assistance needed within 24 weeks after randomization * History of cardiac transplant * Heart rate \< 50 beats per minute or \> 130 beats per minute * Systolic blood pressure \<= 80 mm Hg * Serum creatinine =\> 2.5 mg/dL * Treatment with intravenous vasodilators (including nesiritide) or inotropes within 2 weeks prior to randomization * Receipt of any other investigational agent or device within 4 weeks prior to randomization * Diagnosis of other non-cardiac underlying medical conditions expected to impact their mortality within 24 weeks after randomization * Drug or alcohol dependence, or other conditions which may affect study compliance * History of thyroid disorders of any form within 24 weeks prior to randomization * Use of thyroid supplements (levothyroxine, liothyronine, etc.) or any preparation containing thyromimetic agents within 24 weeks prior to randomization * Supraventricular arrhythmia refractory to conventional treatment, as judged by the investigators