The purpose of this study is to use an immunologic approach following the treatment for recurrent disease in patients with ovarian, fallopian tube, or peritoneal cancer.
Patients with epithelial ovarian, fallopian tube or peritoneal cancer who receive surgical cytoreduction and platinum/taxane containing chemotherapy have a significant chance of entering complete clinical remission but about 70% will eventually relapse. Many patients respond to additional cytotoxic treatment with partial or complete responses, yet approximately 100% of these patients will ultimately progress. Novel consolidation strategies following treatment for recurrent disease are needed and an immunologic approach is an attractive option.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
36
Clinic for Gynecology and Gyn. Oncology, Humboldt University
Berlin, Germany
University Clinic Carl Gustav Carus, Gynecological hospital
Dresden, Germany
Gynecologic Hospital
Düsseldorf, Germany
Safety, feasibility and tolerability
The primary endpoint is drop-out due to toxicity as the overall measure of feasibility
Duration and strength of the immune response induced by ACA 125 vaccination
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
University Gynecologic Hospital
Essen, Germany
University Gynecologic Hospital
Frankfurt, Germany
Gynecologic Clinic of the Ernst-Moritz-Arndt-University
Greifswald, Germany
University Clinic Schleswig-Holstein, Campus Kiel, Clinic for gynecology and obstetrics
Kiel, Germany
Otto-von-Guericke University, University Gynecological Hospital
Magdeburg, Germany
Clinic of the Philipps University Marburg, Clinic for gynecology, gyn. endocrinology and oncology
Marburg, Germany
University Gynecological Hospital
Ulm, Germany
...and 1 more locations