RATIONALE: Drugs used in chemotherapy, such as docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. PURPOSE: This phase II trial is studying how well docetaxel works in treating older women with metastatic breast cancer and whether it helps improve the ability to perform daily activities.
OBJECTIVES: Primary * Determine degree of autonomy in instrumental activities of daily living on-therapy and at 6 and 12 months, as measured by Lawton's Instrumental Activities of Daily Living Scale, in older women with metastatic adenocarcinoma of the breast treated with docetaxel. Secondary * Determine the response rate in patients treated with this drug. * Determine overall and progression-free survival of patients treated with this drug. * Determine the degree of autonomy in daily activities as measured by Katz's Activities of Daily Living Scale, in patients treated with this drug. * Determine mood status, as measured by the Geriatric Depression Scale, of patients treated with this drug. * Determine toxicity of this drug in these patients. OUTLINE: This is a multicenter study. Patients receive docetaxel IV on days 1 and 15. Treatment repeats every 28 days for 6 courses. Ability to perform daily activities is assessed periodically. PROJECTED ACCRUAL: A total of 53 patients will be accrued for this study.
Study Type
INTERVENTIONAL
Purpose
TREATMENT
Masking
NONE
Enrollment
53
Marseille Institute of Cancer - Institut J. Paoli and I. Calmettes
Marseille, France
Institut Curie Hopital
Paris, France
Centre Henri Becquerel
Rouen, France
C.H. Senlis
Senlis, France
Degree of autonomy in instrumental activities of daily living as measured by Lawton's Instrumental Activities of Daily Living Scale during therapy and at 6 and 12 months
Response rate
Overall survival
Degree of autonomy in daily activities as measured by Katz's Activities of Daily Living Scale
Progression-free survival
Mood status as measured by the Geriatric Depression Scale
Toxicity
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