The purpose of the study is to determine the safety and effectiveness of two dose levels of micafungin versus caspofungin in the treatment of proven invasive candidiasis or candidemia.
The purpose of the study is to determine the efficacy and safety of two dose levels of micafungin versus caspofungin in the treatment of proven invasive candidiasis or candidemia. The maximum length of antifungal treatment is 4 weeks except in pre-defined patients where maximum length of therapy is 8 weeks. A post treatment assessment will be conducted at 2 weeks and 6 weeks after the last dose of all antifungal treatments.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
611
IV
IV
Overall treatment success, based on the investigator's assessment of pre-defined clinical and mycological response at the End of intravenous (IV) Therapy
Time frame: End of therapy and 6 weeks post-treatment
Overall treatment success, based on the Data Review Panel's assessment of pre-defined clinical and mycological response at the End of IV Therapy
Time frame: End of therapy and 6 weeks post-treatment
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Birmingham, Alabama, United States
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Little Rock, Arkansas, United States
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Los Angeles, California, United States
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Los Angeles, California, United States
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San Francisco, California, United States
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Denver, Colorado, United States
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Denver, Colorado, United States
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Washington D.C., District of Columbia, United States
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Bay Pines, Florida, United States
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Miami, Florida, United States
...and 157 more locations