Study to Determine the Safety of Two Applications of PEP005 Topical Gel to Actinic Keratoses

Inclusion Criteria: * Male or female patients * At least five individual AK lesions on the arms, shoulders, chest, face and/or scalp Exclusion Criteria: * A cosmetic or therapeutic procedure: * within 10 cm of the selected AK lesions during the 3 months prior to study entry or * anywhere during the 4 weeks prior to study entry or anticipated treatment during the study * Treatment with 5-fluorouracil, imiquimod, diclofenac or photodynamic therapy: * of lesions located within 10 cm of the selected AK lesions during the 3 months prior to study entry or * anywhere during the 4 weeks prior to study entry or anticipated treatment during the study * Use of acid-containing products, topical retinoids or light chemical peels within 10 cm of the selected AK lesions during the 3 months prior to study entry, or anticipated treatment in this same area during the study * Treatment with immuno-modulators, cytotoxic drugs, or interferon/interferon inducers during the 4 weeks prior to study entry or anticipated treatment during the study * Treatment with psoralen plus UVA or use of UVB therapy during the 6 months prior to study entry or anticipated treatment during the study * Use of systemic retinoids during the 6 months prior to study entry or anticipated treatment during the study * Anticipated excessive or prolonged exposure to ultraviolet light or use of topical salves, creams or ointments to the selected AK lesions during the study * Females of childbearing potential