Comparison of the Effects of Two Glaucoma Drugs Over 24 Hours (0507A-137)(COMPLETED)

Merck Sharp & Dohme LLC330 enrolled

Overview

This study is comparing 2 medications for glaucoma and how effective they are at controlling glaucoma over the course of an entire day.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

330

Conditions

Glaucoma Ocular Hypertension

Interventions

MK0507A, dorzolamide hydrochloride (+) timolol maleateDRUG

Comparator: timolol maleateDRUG

Duration of Treatment: Part 1) 6 wk timolol maleate run inDRUG

Part 2) 6 wk washout pd Part 3) two 8 wk active tx pds

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with glaucoma or ocular hypertension Exclusion Criteria: * Other eye conditions * Poor vision * Recent eye surgery * Use of contact lenses * Nursing or pregnant women * Use of some other selected medications * Drug or alcohol abuse * Asthma * Slow heart beat * Allergy or previous reaction to study drugs

Outcomes

Primary Outcomes

24 hour diurnal IOP reduction after 8 weeks of treatment

Time frame: After 8 weeks of treatment

Secondary Outcomes

IOP reduction a) from baseline at 6 weeks; b) comparison with timolol; c) comparison day versus night

Time frame: At 6 weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.