Brain Reaction to Treatment of Nicotine Dependence

US Department of Veterans Affairs104 enrolled

Overview

The purpose of the study was to determine how the treatments for cigarette craving work. Hypothesis: During exposure to cigarette-related cues, heavy smokers will have greater reductions in regional brain activation from before to after both forms of active treatments than from before to after placebo.

PET and fMRI scanning were used to examine brain activity and activation in cigarette smokers in response to cigarette-related cues.

Study Type

INTERVENTIONAL

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

104

Conditions

Nicotine Dependence

Interventions

ZybanDRUG

Eligibility

Sex: ALLMin age: 21 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Heavy smoker, more than one pack per day * Free of medical conditions or medications that affect brain activity * Not pregnant Exclusion Criteria: Drug or alcohol dependence Mental Illness Pregnancy Medications that affect brain function Unstable medical conditions

Locations (1)

VA Greater Los Angeles Healthcare System, West LA

West Los Angeles, California, United States

Outcomes

Primary Outcomes

2-FA PET scan results

Brain activity and activation in response to cigarette-related cues

Time frame: Within the first few weeks of study initiation

Data from ClinicalTrials.gov

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