Non-Nicotine Agents for Smoking Cessation

US Department of Veterans Affairs

Overview

The primary objective of this study is to determine which is the better approach to smoking cessation in veterans: bupropion combined with transdermal nicotine or high dose nicotine replacement therapy (NRT) using transdermal nicotine combined with nicotine inhaler.

This study is a two-arm open-label, randomized controlled trial of bupropion combined with transdermal nicotine versus high dose NRT (transdermal nicotine and nicotine inhaler) with all subjects receiving a behavioral counseling program for smoking cessation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Conditions

Tobacco Use Disorder

Interventions

bupropion and transdermal patchDRUG

transdermal patch and nicotine inhalerDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Readiness to set a quit date in the next two weeks, * Current smoking of at least 15 cigarettes a day Exclusion Criteria: * Current untreated depression or receiving treatment for depression, * History of seizures, major head injury, or other predisposition for seizures

Locations (1)

Denver VA Medical Center

Denver, Colorado, United States

Data from ClinicalTrials.gov

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