Opioid Growth Factor in Treating Patients With Advanced Pancreatic Cancer That Cannot Be Removed By Surgery

Inclusion criteria * Diagnosis of pancreatic cancer * Advanced, unresectable disease * Must have failed OR refused prior standard chemotherapy (e.g., gemcitabine or fluorouracil) for pancreatic cancer * Measurable disease by radiography * Age Over 18 * Performance status Karnofsky 50-100% * Hematopoietic * Absolute neutrophil count ≥ 1,500/mm\^3 * WBC ≥ 3,500/mm\^3 * Hemoglobin ≥ 8.5 g/dL * Platelet count ≥ 100,000/mm\^3 * Bilirubin ≤ 4.0 mg/dL (stents allowed) * PT or INR ≤ 2 seconds over control OR ≤ 1.8 (unless on warfarin) renal \& metabolic * BUN ≤ 30 mg/dL (hydrated) * Creatinine ≤ 2.0 mg/dL * Sodium ≥ 130 mmol/L * Potassium ≥ 3.2 mmol/L * Glucose 60-300 mg/dL * Pulse 60-110 beats/minute * Systolic blood pressure 90-170 mm Hg Exclusion Criteria * No primary CNS tumors or known brain metastases Cardiovascular * \- congestive heart failure * symptoms of coronary artery disease * cardiac arrhythmia * poorly controlled hypertension * myocardial infarction within the past year * abnormal EKG * asthma * hronic obstructive pulmonary disease * pregnant or nursing * Fertile patients must use effective contraception * serious infection requiring antibiotics within the past 2 weeks * poorly controlled diabetes * seizure disorders * fever \> 37.8° C * other malignancy within the past 5 years * concurrent chemotherapy * concurrent oral steroids * concurrent radiotherapy * Surgery within 4 weeks