131-I-TM-601 Study in Adults With Recurrent High-Grade Glioma

Inclusion Criteria: * Patient must have a histologically confirmed unilateral, supratentorial malignant glioma (grade 3 or 4, anaplastic astrocytoma, gliosarcoma, glioblastoma multiforme or malignant oligoastrocytoma) * Patient must have glioma progression or recurrence following radiotherapy that was no less than 50 Gy (+/- chemotherapy; +/- surgery) * Patient must be a candidate for resection of the recurrent tumor (surgical requirements are detailed in the study protocol) * Imaging must show recurrent, unilateral, supratentorial tumor(s) * There is no diffuse leptomeningeal disease * For patients with previous radiosurgery or enhanced radiotherapy, based on neurosurgeon's judgment, the area of enhancement can be removed during the surgery * Patient must have recovered from toxicity of prior therapy * Patient must be \> 18 years of age. * Patient has a Karnofsky Performance Status greater than or equal to 60% * Patient must have a life expectancy of at least 3 months * Patient has no uncontrolled seizures or other neurological conditions which would interfere with evaluation * Patient is not currently receiving, or is not anticipated to receive, concomitant anticancer agent(s) during the course of this study * Patient must have given informed consent Exclusion Criteria: * Patient with concurrent malignancy (except curatively treated basal or squamous cell carcinoma of the skin or carcinoma in situ of cervix and/or breast) or patients with prior malignancies that have not been disease-free for five years * Patient has presence of non-contiguous satellite lesions * Patient with known allergy to iodine, iodine containing drugs or contrast agent * Patient with the potential for pregnancy or impregnating their partner and who do not agree to follow an acceptable birth control method to avoid conception * Pregnant or breast feeding females * Patient is not maintained on a stable corticosteroid regimen * New onset of conditions not present prior to surgery (as detailed in Study Protocol) which would make patient an inappropriate study candidate, or as determined by Investigator