This is a Phase II research study that is designed for patients who have small cell lung cancer (SCLC) that is no longer responding to treatment. Patients will receive picoplatin, a new platinum-based agent that is currently under investigation, in 21-day cycles.
Platinum drugs work by binding to DNA and preventing the rapid cell division of tumors. However, many tumors demonstrate a resistance to platinum drugs. Results from preclinical studies indicate that picoplatin (previously called AMD473 or ZD0473) may be able to overcome or partially overcome platinum resistance. More than 500 patients have received picoplatin in previous Phase I or Phase II clinical trials.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
75
Efficacy and safety (outcomes will be measured approximately 1 year after the last subject has been treated)
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Genesis Cancer Center
Hot Springs, Arkansas, United States
Study Site
Los Angeles, California, United States
Comprehensive Cancer Center
Palm Springs, California, United States
Eastern Connecticut Hematology/Oncology
Norwich, Connecticut, United States
Oncology Hematology Group of South Florida
Miami, Florida, United States
H. Lee Moffitt Cancer Center
Tampa, Florida, United States
Augusta Oncology Associates
Augusta, Georgia, United States
Central Georgia Hematology Oncology Associates
Macon, Georgia, United States
Georgia Cancer Specialists
Tucker, Georgia, United States
Rush Medical College
Chicago, Illinois, United States
...and 45 more locations