This is a randomized, open-label study to evaluate pituitary ovarian suppression in healthy, reproductive-aged women using three different regimens of oral contraceptives (OCs). Two extended regimen OCs, Seasonale (levonorgestrel/ethinyl estradiol 0.15/0.03 mg for 84 days followed by 7 days of placebo), and Seasonique (levonorgestrel/ethinyl estradiol 0.15/0.03 mg for 84 days followed by 7 days of ethinyl estradiol 0.01 mg), and a 28-day regimen OC, Portia (levonorgestrel/ethinyl estradiol 0.15/0.03 mg for 21 days followed by 7 days of placebo).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
36
Duramed Investigational Site
Temple, Texas, United States
Compare differences in hormone patterns (follicle stimulating hormone [FSH], luteinizing hormone [LH], inhibin-B, and estradiol)
Time frame: Before, during and after the 7-day hormone free interval or EE-supplemented interval
Compare the differences in hormone withdrawal symptoms
Time frame: Before, during and after the 7-day hormone free interval or EE-supplemented interval
Compare differences in ovarian follicular development
Time frame: Before, during and after the 7-day hormone free interval or EE-supplemented intervals
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