Safety and Effectiveness of NXY-059 for the Treatment of Patients Who Have Suffered From a Stroke

Inclusion Criteria: * Males and females * Acute ischemic stroke with limb weakness, onset of symptoms within 6 hours * Full functional independence prior to the present stroke Exclusion Criteria: * Unconsciousness * Subjects who are unlikely to complete the infusion of investigational product and/or are unlikely to undergo active medical management during that period due to a severe clinical condition * Severe illness with life expectancy less than 6 months * Known severe kidney disorder * Current known alcohol or illicit drug abuse or dependence * Pregnant or breast-feeding * Treatment with acetazolamide and methotrexate is not permitted during the infusion * Participation in a previous clinical study within 30 days