The researchers hypothesize that the addition of nesiritide to standard therapy will prevent worsening of renal function in patients admitted to the hospital with decompensated heart failure and renal dysfunction relative to standard therapy alone.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
34
Nesiritide: 1 mcg/kg bolus, followed by a continuous infusion at 0.005 mcg/kg/min which can be titrated every 3 hours by 0.005 mcg/kg/min to maximum dose of 0.03 mcg/kg/min until adequate diuresis achieved.
Brigham and Women's Hospital
Boston, Massachusetts, United States
Renal function
Time frame: within 7 days after randomization
Weight loss
Time frame: Within 7 days from randomization
Days to optimal volume status
Time frame: From randomization till day 7 or sooner
Concomitant diuretic use
Time frame: Within 7 days from randomization
Global symptom assessment
Time frame: 24 hrs and 3 days after randomization
Length of stay
Time frame: From admission to discharge or day 7
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.