Safety of and Immune Response to an Experimental HIV Vaccine (VRC-HIVADV014-00-VP) in HIV Uninfected Adults

Inclusion Criteria: * Have access to a participating site and are willing to be followed for the duration of the study * Willing to receive HIV test results * Able to understand and comply with study requirements * In good general health * Have neutralizing adenovirus antibody levels that are less than a 1:12 ratio * Agree to use acceptable methods of contraception for at least 21 days prior to study start and for the duration of the study. Exclusion Criteria: * HIV infected * Positive hepatitis B surface antigen * Positive anti-hepatitis C virus antibodies * Prior receipt of an HIV vaccine * Immunosuppressive drugs within 168 days prior to first vaccination * Have received donated blood within 120 days prior to first vaccination * Have received immunoglobulin within 60 days of the first vaccination * Live attenuated vaccines or investigational research agents within 30 days prior to first vaccination * Subunit or killed vaccines within 14 days prior to first vaccination * Current preventive or therapeutic anti-tuberculosis (TB) treatment * Any medical, psychiatric, or social condition that would interfere with the study * Any occupational or other responsibility that would interfere with the study * Serious adverse reactions to vaccines * Autoimmune disease * Immunodeficiency * Active syphilis infection. Participants who have been fully treated for syphilis over 6 months prior to study entry are not excluded. * Asthma. Participants who have had completely resolved childhood asthma are not excluded. * Diabetes mellitus type I or II. Participants who have had isolated gestational diabetes are not excluded. * Thyroid disease or removal of the thyroid * Blood vessel swelling within the last 3 years * Uncontrolled hypertension * Body mass index (BMI) of 40 or higher * Bleeding disorder * Cancer. Participants whose cancer has been removed and is unlikely to recur during the study are not excluded. * Seizure disorder. Participants who have not required medication or had a seizure for 3 years prior to study entry are not excluded. * Removal of the spleen or have a nonfunctioning spleen * Psychiatric conditions that may interfere with the study * Pregnancy, breastfeeding, or plan to become pregnant during the study