Changes in Cardiovascular Hemodynamics During Peritoneal Dialysis

N/ATerminatedNCT00119990

University of Aarhus15 enrolled

Overview

During peritoneal dialysis, water is removed from the body. This sometimes occurs at rates of up to 500 ml/h. During shifts with dialysate with high glucose content, an increase in blood pressure has been described. The effect upon central hemodynamics is unknown. The researchers are investigating the effects of low and high glucose dialysate and icodextrin on cardiac output, stroke volume, pulse rate and blood pressure. The researchers have hypothesized that the effects seen are induced by vasopressin.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Peritoneal Dialysis

Interventions

Icodextrin (dialysate)DRUG

2 liter of extraneal are given with one fill for 4 hours.

Physioneal (dialysate) 1.36% and 2.27%DRUG

2 liter of Physioneal of 1.36% or 3.86% are given with one fill for 4 hours one two different days.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Peritoneal dialysis patients Exclusion Criteria: * Insulin dependent diabetes mellitus * AV-fistula, cardial arrhythmia persistence, or severe cardiac and lung disease * Recent infectious disease * Severe psychiatric disease * Hypersensitivity to icodextrin

Locations (1)

Deparment of Renal Medicine, Skejby Hospital

Aarhus, Denmark

Outcomes

Primary Outcomes

Changes in cardiac hemodynamics. (Cardiac Output, stroke volume, pulse rate, blood pressure and total peripheral resistance)

Time frame: 4 hours

Data from ClinicalTrials.gov

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