The Effect of Fasudil on Vascular Function in Humans

Phase 2CompletedNCT00120718

Brigham and Women's Hospital60 enrolled

Overview

The purpose of the study is to evaluate how the rho kinase inhibitor, fasudil, affects vascular function in patients with atherosclerosis and hyperlipidemia.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Atherosclerosis Hypercholesterolemia

Interventions

fasudilDRUG

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Coronary artery disease * Hyperlipidemia -OR- * Healthy adults Exclusion Criteria: * Unstable angina, myocardial infarction or revascularization within 3 months * Symptomatic heart failure * Creatinine \> 3.0 mg/dl * Liver enzymes \> 3X upper limit of normal * Chronic hypoxia * Significant anemia * Chronic inflammatory disease * Pregnancy * Willing to withdraw statins for duration of study

Locations (1)

Brigham and Women's Hospital

Boston, Massachusetts, United States

Outcomes

Primary Outcomes

Vascular reactivity

Secondary Outcomes

Rho kinase expression

Rho kinase activity

eNOS expression

eNOS activity

inflammatory markers

Data from ClinicalTrials.gov

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