Visudyne® in Occult (VIO)

Inclusion Criteria: * Patients are men or women age 50 years or older. * Patients must have occult CNV secondary only to AMD in the study eye, without any other concurrent retinal disease present that may also be associated with CNV (e.g., pathologic myopia, ocular histoplasmosis syndrome, etc.). In the case that both eyes are eligible, only one eye will be treated and the decision of which eye will be treated will be made between the patient and physician. * Patients must have blood associated with the lesion or must have shown a progression of the disease within the preceding 3 months before randomization to treatment. For the purpose of this study, disease progression is defined as either: * a documented loss of vision (six or more letters with the ETDRS chart or at least three lines with a Snellen chart) using best-corrected visual acuity assessments; or * documented fluorescein angiographic evidence of a 10% increase in the lesion's greatest linear dimension. * Patients must have lesions in the study eye with the following characteristics as determined by fluorescein angiography: * Evidence that occult CNV involves the geometric center of the foveal avascular zone; * The lesion has only occult CNV with no classic CNV; * The area of occult CNV must occupy at least 50% of the total lesion. * Patients must have a best-corrected visual acuity score in the study eye between 73 and 34 letters (approximate Snellen equivalent of 20/40 to 20/200), inclusive. Visual acuity will be measured with an ETDRS chart using the procedure developed for the TAP/VIP studies. * Patients must meet at least one of the following criteria: * CNV lesion ≤4 MPS disc areas; * Visual acuity score \<65 letters. * Female patients of child-bearing potential must not be pregnant or lactating, must have a negative pregnancy test (serum or urine) at baseline and must be practicing an adequate method of birth control. Acceptable methods of birth control include intrauterine device (IUD); oral, implanted or injected contraceptives; and barrier methods with spermicide. * Patients must sign an approved informed consent that complies with relevant regulatory requirements prior to undergoing any study-related procedures. Exclusion Criteria: * Patients with a greatest linear dimension (GLD) of the entire lesion that exceeds 5400 microns * Patients with a lesion size \>6 MPS disc area (15.24 mm2) * Patients with a CNV lesion size that is \>4 MPS disc areas associated with a best-corrected visual acuity score that is \>=65 letters (approximate Snellen equivalent of 20/50 or better) at the initial visit. * Patients who have a known hypersensitivity/allergy to Visudyne, porfimer sodium, or other porphyrins; porphyria or other porphyrin sensitivity; or hypersensitivity to sunlight or bright artificial light. * Patients who have the following in the study eye: a tear (rip) of the RPE; a vitelliform-like lesion of the outer retina (e.g., as in pattern dystrophies or basal laminar drusen); idiopathic parafoveal telangiectasis, retinal lesion anastomosis, or central serous retinopathy. * Patients with a known allergy to fluorescein dye. * Patients who have any additional ocular diseases which have irreversibly compromised or, during follow-up, could likely compromise the visual acuity of the study eye including amblyopia, elevated intraocular pressure (≥30 mm Hg), anterior ischemic optic neuropathy, clinically significant diabetic macular edema, severe non proliferative diabetic retinopathy, proliferative diabetic retinopathy or cataract (lens or capsule) obscuring easy identification of the CNV lesion on biomicroscopy or fluorescein angiography. * Patients who are unable to be photographed to document CNV, e.g., due to media opacity, cataract obscuring the CNV, allergy to fluorescein dye, or lack of venous access. * Patients who have had treatment for CNV in the study eye with photodynamic therapy (PDT), transpupillary thermotherapy (TTT), or other local treatment (such as submacular surgery). Previous laser photocoagulation therapy is acceptable, provided it was not subfoveal. * Patients who are participating in any other clinical study or are receiving, or have received any experimental systemic treatment for AMD (e.g., retinoic acid, thalidomide) or any other investigational new drug within 12 weeks prior to the start of study treatment. * Patients who have undergone intraocular surgery within the last two months or Nd:YAG capsulotomy within the last month in the study eye. * Patients who have a history of moderate to severe hepatic impairment (patients with this history may be included if laboratory tests are performed and results indicate that they are within the normal limits).