A Study of Preoperative Radiation Therapy and Capecitabine in Locally Advanced Rectal Cancer

Alberta Health services66 enrolled

Overview

The purpose of this trial is to study the efficacy of preoperative radiation therapy and capecitabine in locally advanced rectal cancer.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Rectal Cancer Neoplasm Metastasis

Interventions

CapecitabineDRUG

Pelvic radiationPROCEDURE

Eligibility

Sex: ALLMin age: 17 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Biopsy - proven rectal cancer * Transmural rectal wall invasion * Karnofsky performance status \>70 * Normal bone marrow, liver and kidney function Exclusion Criteria: * Distant metastases * Prior pelvic radiation * Inflammatory bowel disease * Severe ischemic heart disease * Anticoagulant therapy * Pregnancy

Locations (1)

Tom Baker Cancer Centre

Calgary, Alberta, Canada

Outcomes

Primary Outcomes

safety

response

Data from ClinicalTrials.gov

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