Intra-arterial Microplasmin Administration in Patients With Acute Intracranial Vertebrobasilar Artery Occlusion

Inclusion Criteria: 1. Patients with angiographically documented vertebrobasilar artery occlusion 2. Initiation of study drug treatment within 24 hours of the onset of neurological symptoms 3. Age 18-75 (inclusive). Exclusion Criteria: 1. Patients with coma \> 6 hrs duration and complete loss of brain stem reflexes (corneal reflex, gag reflex, VOR, pupil reflexes) as measured at the last assessment before sedation/intubation 2. Rapidly improving neurologic signs at any time before initiation of study drug administration. 3. Known contrast agent-sensitivity 4. Uncontrolled hypertension defined as a systolic blood pressure \> 180 mm Hg or a diastolic blood pressure \> 100 mm Hg on 3 separate occasions at least 10 minutes apart or requiring continuous IV therapy. 5. History of stroke within the previous 6 weeks.