Triptorelin for Ovary Protection in Childhood Onset Lupus

Inclusion Criteria: * Females under the age of 21 and non-pregnant * Tanner stage of 2 or above as determined by physical examination of breast stage * Diagnosis with SLE using the updated American College of Rheumatology (ACR) Classification Criteria for SLE 1 * Severe SLE requiring cyclophosphamide therapy * Bone mineral density z-score \> - 2.0 * Must be using a medically acceptable form of birth control during the study and must not be pregnant at the screening visit * No clinically significant abnormal findings other than those consistent with the diagnosis of childhood-onset SLE (cSLE) on the physical examination, medical history or clinical laboratory results during screening * Currently on any combination of medication but must not have been treated with more than one dose of cyclophosphamide or other gonadotoxic medications in the past * Voluntary consent or, if under the age of consent, assent to participate in this study with permission by a legal guardian Exclusion Criteria: * Male patients of any age * Female patients with a Tanner stage of 1 * Positive blood pregnancy test at screening or taking oral or injectable birth-control medications * Prior exposure to more than one dose of gonadotoxic medications including cyclophosphamide * History of allergic or adverse response to triptorelin * Diagnosed with hypogonadism prior to cyclophosphamide exposure * Acutely life-threatening disease activity that prohibits inclusion in a clinical trial * History of clinically significant gastrointestinal tract, renal, hepatic, endocrine, oncologic, pulmonary (asthma accepted), or cardiovascular disease; or a history of tuberculosis, epilepsy, diabetes, depression, psychosis, or any other non-cSLE condition, which in the opinion of the physician, would jeopardize the safety of the subject or impact the validity of the study results * Patient age 18 years of younger with severe depression as defined by a CDI (Children's Depression Inventory) score of \> 23 or a patient age 19 to 21 years with severe depression as defined by a BDI (Beck's Depression Inventory) score \> 29 * Patient admits to suicidal thoughts at screening visit * Bone mineral density lower than z = -2.0.