Treating Nicotine Dependence in Schizophrenic Individuals: Effectiveness of Bupropion - 1

Inclusion Criteria: * DSM-IV diagnosis of schizophrenia or schizoaffective disorder and nicotine dependence * Fagerstrom Test for Nicotine Dependence (FTND) score greater than 5 * Smokes at least 20 cigarettes per day (1 pack per day) * Expired breath CO level \> 10 ppm and cotinine level \> 210 ng/ml at the baseline measurement * Currently taking a stable dose of antipsychotic * Complete remission from positive symptoms of psychosis as judged by a psychiatric evaluation Exclusion Criteria: * Meets criteria for current abuse or dependence for any alcohol or illicit substance within the past month * History of hypersensitivity to bupropion or the nicotine transdermal patch (NTP) * Current diagnosis of a serious documented medical disorder that would make bupropion treatment risky OR results of psychiatric/medical screening that suggest a reason for concern (e.g., a history of severe heart, liver, or kidney disease or diabetes mellitus) * Currently taking monoamine oxidase inhibitors or bupropion (Zyban or Wellbutrin) * Currently taking diabetes mellitus medications, St. John's Wort, appetite suppressants, ephedrine-containing medications, theophylline, clonidine, reserpine, methyldopa, or anti-anginal medications (e.g., beta-blockers, calcium channel blockers, nitroglycerin preparations) * History of schizoaffective disorder and not stabilized on a mood stabilizer (e.g., lithium, valproate, carbamazepine)