Trial of Terbutaline for the Treatment of Status Asthmaticus in Children

Connecticut Children's Medical Center40 enrolled

Overview

Although widely used for the treatment of pediatric status asthmaticus, intravenous terbutaline has potentially significant side effects; may not improve outcomes; and may increase Intensive Care Unit (ICU) length of stay. This study is designed to test the efficacy of intravenous terbutaline for the treatment of status asthmaticus by adding intravenous terbutaline or placebo to standard asthma treatment. The dose of terbutaline or placebo will be titrated according to severity of illness as quantified by a validated clinical asthma score. Differences in outcomes between the study groups, such as length of stay, hospital costs, and lung function will be compared.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Status Asthmaticus

Interventions

Eligibility

Sex: ALLMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Admission to the Connecticut Children's Medical Center (CCMC) Pediatric Intensive Care Unit (PICU) with a primary admission diagnosis of status asthmaticus * Modified Pulmonary Index Score (MPIS) of greater than or equal to 12 * Age between birth and 18 years old Exclusion Criteria: * Pre-existing cardiac or pulmonary disease * Existing respiratory failure (requiring invasive or non-invasive mechanical ventilation) * Hemodynamic or cardiovascular instability requiring inotropic support * The patient meets one of the criteria for withdrawal from the study due to patient safety concerns

Outcomes

Primary Outcomes

ICU length of stay

Secondary Outcomes

To evaluate the effects of intravenous terbutaline on pulmonary mechanics over length of ICU admission

To prospectively analyze the side effects of terbutaline