The purpose of this study is to determine whether stem cell mobilization by granulocyte colony-stimulating factor (G-CSF) therapy in patients with acute myocardial infarction after successful mechanical reperfusion reduces infarct size.
Experimental studies and early-phase clinical trials suggest that transplantation of blood-derived or bone marrow-derived progenitor cells may improve cardiac regeneration after acute myocardial infarction. Granulocyte colony-stimulating factor (G-CSF) induces mobilization of bone marrow stem cells and, thereby, increases the number of circulating stem cells that are available cells for myocardial regeneration.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
114
Patients were randomly assigned to receive subcutaneously a daily dose of 10 microg/kg of G-CSF for 5 days.
Patients were randomly assigned to receive subcutaneously either a daily dose of 10 microg/kg of G-CSF or placebo for 5 days.
Deutsches Herzzentrum
Munich, Germany
671. Medizinische Klinik, Klinikum rechts der Isar
Munich, Germany
Reduction of infarct size (measured by Tc-sestamibi scintigraphy)
Time frame: measured by Tc-sestamibi scintigraphy baseline, 4 and 6 months
Left ventricular ejection fraction
Time frame: Left ventricular ejection fraction
Incidence of angiographic restenosis
Time frame: 6 months
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