Prophylactic Antibiotics on Urethral Catheter Withdrawal

St. Antonius Hospital100 enrolled

Overview

Urinary-tract infection (UTI) is the most common type of hospital-acquired infection (30% of all). The purpose of this study is to determine whether antibiotic prophylaxis for urinary catheter removal is useful at preventing catheter-associated urinary-tract infection.

Urinary-tract infection (UTI) is the most common type of hospital-acquired infection (30% of all). The researchers undertake a double-blind, placebo-controlled trial to assess the efficacy of single-dose therapy of trimethoprim-sulfamethoxazole or ciprofloxacin, versus placebo therapy in selected groups of surgical patients who had bladder drainage scheduled to last longer than 3 days.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

100

Conditions

Urinary Tract Infection Bacteriuria

Interventions

trimethoprim-sulfamethoxazoleDRUG

ciprofloxacinDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Urethral catheter in situ for at least 3 days (72h) Exclusion Criteria: * Pregnancy * Impaired renal or hepatic function (serum creatinine \> 150 mmol/l, serum transaminases \> 75 IU/l) * Fever * Symptomatic urinary tract infection * Antibiotic use ≤ 48 hours before urinary catheter removal * Allergy to trimethoprim-sulfamethoxazole or ciprofloxacin * Urologic pathology

Locations (1)

Sint Antonius Hospital

Nieuwegein, Utrecht, Netherlands

Outcomes

Primary Outcomes

Symptomatic bacteriuria

Asymptomatic bacteriuria

Secondary Outcomes

Antibiotic resistance patterns

Data from ClinicalTrials.gov

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