A Comparison of SmartPill Capsule With Scintigraphy for Determining Gastric Residence Time

Inclusion Criteria: Inclusion Criteria For Healthy Subjects: 1. Healthy males and females between ages 18-65 years of age with no gastrointestinal disease as screened by the GI Disease Screening Questionnaire 2. Average bowel movement frequency of at least one bowel movement within 48 hours 3. Subjects with high probability for compliance and completion of the study Inclusion Criteria For Subjects with Gastroparesis: 1. Abnormal gastric emptying as defined by local standards and documented by nuclear medicine scintigraphy performed within the last two years. 2. Males and females between ages 18-65 years of age. 3. Average bowel movement frequency of at least one bowel movement within 72 hours 4. Subjects with high probability for compliance and completion of the study 5. Upper endoscopy or upper GI within last 3 years showing no evidence of gastric bezoar, stricture, or peptic ulcer. Exclusion Criteria: Exclusion Criteria For Healthy Subjects: 1. Prior GI surgery 2. Surgery within the past 3 months 3. Diverticulitis 4. Tobacco use within eight hours prior to capsule ingestion and during the 8 hour monitoring time. 5. Alcohol use within 24 hours prior to capsule ingestion and throughout the entire monitoring period (up to 72 hours). 6. Body mass index (BMI) \> 35 7. Allergies to components of the test meal including eggs, bread, and jam. 8. Female of childbearing age who is not practicing birth control and/or is pregnant or lactating. (Confirm with urine pregnancy test) 9. Cardiovascular, endocrine, renal, or other chronic disease likely to affect motility. Exclusion Criteria For Subjects with Gastroparesis: 1. History of gastric bezoar 2. Severe dysphagia to solid food and pills 3. Severe vomiting more than 1 time per day 4. Diverticulitis 5. Severe daily abdominal pain requiring medications for relief 6. Severe weight loss, greater than 10 lbs over the preceding 2 months. 7. Uncontrolled diabetes with a hemoglobin A1C greater than 10. 8. Excessively delayed gastric emptying time: more than 90% of a standard egg meal retained after 2 hours. 9. Previous gastro-esophageal surgery including vagotomy, fundoplication, gastric bypass, ulcer surgery. 10. Prior GI surgery except for uncomplicated appendectomy and laparoscopic cholecystectomy 11. Surgery within the past 3 months 12. Tobacco use within eight hours prior to capsule ingestion and during the 8 hour monitoring time. 13. Alcohol use within 24 hours prior to capsule ingestion and throughout the entire monitoring period (up to 72 hours). 14. BMI \> 35 15. Allergies to components of the test meal including eggs, bread, and jam 16. Female of childbearing age who is not practicing birth control and/or is pregnant or lactating. (Confirm with urine pregnancy test)