Ketoconazole Administration: How it is Affected by the Body and Broken Down and How it Acts on the Body When Used With Velcade

Inclusion Criteria: * Male and female patients 18 years of age or older, with a diagnosis of advanced solid tumor for which no curative or other treatment of higher priority is available * Karnofsky Performance Status (KPS) equal to or greater than 70% * Normal liver function tests (aspartate transaminase \[AST\] or alanine transaminase \[ALT\] equal to or less than 2 x upper limit of normal \[ULN\]) * Total bilirubin equal to or less than 1.5 x ULN * Calculated creatinine clearance equal to or greater than 50 mL/min * Normal serum calcium Exclusion Criteria: * Patients with significant cardiac disease * Equal to or greater than Grade 2 neuropathy * Active hepatitis * HIV infection * Secondary malignancy * Transfusion-dependent or received extensive radiation therapy, systemic chemotherapy, or other antineoplastic therapy within 4 weeks of enrollment * Patients taking concomitant medications having inhibitory or inducing activity for CYP 3A4