Usefulness of Selegiline as an Aid to Quit Smoking - 1

Inclusion Criteria: * Meets DSM-IV criteria for nicotine dependence with a Fagerstrom Test of Nicotine Dependence (FTND) score greater than 5 * Smokes at least 15 cigarettes daily (averaged over 1 week, within the month prior to enrollment) * Motivated to quit smoking within 30 days at time of initial evaluation * At least one unsuccessful attempt to quit smoking in the past year * An expired breath CO level greater than 10 ppm and baseline plasma cotinine level greater than 150 ng/ml at initial evaluation * Body weight of at least 100 lb * Avoidance of nicotine replacement product use one month prior to enrollment * Speaks English Exclusion Criteria: * Currently taking over-the-counter or prescription sympathomimetic agents (e.g., pseudoephedrine, methylphenidate), antidepressant agents (e.g., tricyclic antidepressants, serotonin reuptake inhibitors, bupropion, other monoamine oxidase inhibitors), or meperidine (Demerol) * Serious medical disorders such as unstable angina or liver failure * Abnormalities in baseline bloodwork (e.g., threefold elevation of liver function tests, electrolyte abnormalities) * Physiologically dependent on and/or abusing alcohol or other drugs of abuse (e.g., cocaine, opiates, benzodiazepines, etc.) during the 6 months prior to enrollment (based on a clinical evaluation, which includes a self-report, and is confirmed by a positive urine toxicology screen) * Meets DSM-IV criteria for a current diagnosis of major depressive disorder, panic disorder, or post-traumatic stress disorder * Current or past history of bipolar disorder or schizophrenia * Past history of major depression associated with historical evidence of suicidal or homicidal behavior, or psychotic symptoms * Currently residing with another study participant * Presence of suicidal or homicidal ideation * Significant impairment of social or occupational functioning, either at time of initial evaluation or during the trial * Known hypersensitivity to selegiline hydrochloride