Effect of Ketalar to Prevent Postoperative Chronic Pain After Mastectomy

Hospices Civils de Lyon40 enrolled

Overview

Prevalence of chronic pain after mastectomy is beyond 50% 3 months after surgery. This pain is related to a sensitization of the central nervous system through N-methyl-D-asparate (NMDA) receptors. Ketalar might prevent the occurrence of chronic pain by anti-NMDA properties after mastectomy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Pain Breast Cancer

Interventions

ketalarDRUG

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Mastectomy in patients 18 to 80 years old Exclusion Criteria: * American Society of Anesthesiology (ASA) class \>= 3 * Renal, heart or hepatic failure * Allergy to ketalar * Psychiatric disease * Chronic antalgic treatment

Locations (1)

Centre Hospitalier Lyon Sud

Pierre-Bénite, France

Outcomes

Primary Outcomes

To evaluate the effect of perioperative ketalar on pain intensity 3 months after a mastectomy

Pain intensity is evaluated by an appropriate questionnaire 1 and 3 months after surgery.

Secondary Outcomes

To evaluate the incidence of chronic pain after mastectomy, the impact on life quality, and the area of hyperalgesia

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.