Study to Evaluate the Performance and Safety of Expedial and Compare it to Expanded Polytetrafluoroethylene (ePTFE) Vascular Access Grafts

Inclusion Criteria: * Patient has chronic renal failure and requires vascular access for hemodialysis * Patient has given informed consent to participate in the trial and is willing to comply with the study protocol * Patient is male or female, 18 years of age or older * The vascular access graft can be placed in the upper extremity (forearm, including across the elbow, or upper arm) * Patient is undergoing or will undergo hemodialysis at a hospital or hemodialysis center * Patient has a vein 4 mm or larger to which the graft can be anastomosed Exclusion Criteria: * Patient is unable to comply with the study follow-up * Patient has a known sensitivity to polyurethane or porcine heparin * Patient has a previous vascular access graft implanted and it is not possible to place the study graft proximal to the existing device and no other sites are available * Patient has an immunodeficiency syndrome * Patient has a prior history of bacterial infection within 8 weeks of implantation of graft * Patient has a severe coagulation disorder * Patient has an elevated platelet count of greater than 1 million * Patient has a history of heparin-induced thrombocytopenia syndrome (HIT) * Patient is pregnant * Patient has a fever greater than 100 degrees Fahrenheit