EMD 273066 in Patients With Recurrent EpCAM Positive Ovarian, Prostate, Colorectal or Non-small Cell Lung Cancers When First Given Cyclophosphamide

Inclusion Criteria: * Recurrent non-small cell lung, colorectal, ovarian or prostate cancer * No more than two lines of prior chemotherapy * Positive EpCAM expression * Karnofsky Performance Status \> 70% * Adequate laboratory results * Normal cardiac stress test Exclusion Criteria: * Evidence of brain metastases * Pregnant or lactating females * Significant infection * Prior receipt of EMD 273066 * Unable to interrupt anti-hypertensive medications 2 days prior to and through each cycle of study medication administration * Uncontrolled hypertension * Previous diagnosis of Addison's disease * Previous diagnosis of an autoimmune disease * Organ transplant * Insulin-dependent diabetes * History of acute pancreatitis * Congestive heart failure