TNFalfa Blocking Treatment of Spondylarthropathies

Hvidovre University Hospital50 enrolled

Overview

The purpose of the study is to establish a Danish cohort of spondylarthropathy (SpA) patients who are being treated with TNFalfa blockers. By following the TNFalfa blocking treated patients the researchers want to identify better biomarkers for disease activity and disease progression. In addition, the researchers want to identify predictors for disease progression.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Spondylarthropathies Ankylosing Spondylitis Psoriatic Arthritis

Interventions

InfliximabDRUG

EtanerceptDRUG

AdalimumabDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age\>18 years old * Spondylarthropathies according to the European Spondylarthropathy Study Group (ESSG) criteria * Sacroiliitis by X-ray or magnetic resonance imaging (MRI) * Bath Ankylosing Spondylitis Disease Activity Index (BASDAI)\>3 * No signs of tuberculosis (TB) * Sufficient contraception Exclusion Criteria: * Wish of pregnancy or nursing * Previous treatment with TNFalfa blocker * Disease-modifying anti-rheumatic drugs (DMARDs) other than methotrexate (MTX) later than 4 weeks before inclusion * Steroid treatment later than 4 weeks before inclusion * Immunosuppressing agents later than 4 weeks before inclusion * Severe infections within 3 months * HIV-infection * Active hepatitis B and C * Active or latent TB * Severe chronic diseases * Heart insufficiency (New York Heart Association \[NYHA\] 3 and 4) * Malignancy * Systemic lupus erythematosus (SLE) or SLE-like disease * Abuse of narcotics or alcohol * Major psychiatric disorders

Locations (9)

Rigshospitalet

Copenhagen, Denmark

Bispebjerg Hospital

Copenhagen, Denmark

Gentofte Hospital

Gentofte Municipality, Denmark

Glostrup Hospital

Glostrup Municipality, Denmark

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.