A Study Of 6-Month Duration To Evaluate The Weight Loss Effect Of Various Doses Of CP-945,598 In Obese Subjects

Inclusion Criteria: * Male and/or female subjects without clinically relevant abnormalities identified by a detailed medical history, full physical examination, including blood pressure and pulse rate measurements, 12 lead ECG and clinical laboratory tests * Body Mass Index (BMI) ³30 and \<40 kg/m2, for subjects with no additional * co morbidities; BMI ³27 kg/m2 and \<40 kg/m2, for subjects with co morbidities \[history of essential hypertension and/or dyslipidemia defined as high LDL (³160 mg/dL) or high total cholesterol (³240 mg/dL)\]; Exclusion Criteria: * Subjects with resting sitting systolic blood pressure of 140 mmHg or greater or diastolic blood pressure of 90 mmHg or greater. * Subjects with type 2 diabetes or fasting blood glucose concentration ³126 mg/dL; * Subjects with a history of eating disorders like anorexia nervosa or bulimia nervosa * Subjects on prescription and non-prescription appetite or weight modifying drugs