Variable Bolus Regimen 1-2-3 for Type 2 Diabetes Mellitus

Subjects with type 2 diabetes mellitus who have been using a stable combination oral antidiabetic therapy of 2 or 3 agents in different therapeutic classes for on at least 3 months will be enrolled in this study. Inclusion Criteria: * Male and female subjects 18 to 79 years of age with a diagnosis of type 2 diabetes mellitus for at least 6 months * Current treatment with a stable dose of 2 oral antidiabetic agents. The oral agents must be in 2 or 3 of the following 3 different classes: * Sulfonylurea: dosage greater than or equal to, one-half the maximum recommended dosage (eg, glimepiride \>/= 4 mg; glipizide, including gastrointestinal therapeutic system \[GITS\], \>/= 10 mg; glyburide \>/= 10 mg; Glynase® \>/=3 mg). The dosage must have been stable for at least 3 months prior to screening. * Biguanide: metformin dosage ≥ 1000 mg daily, including Glucophage XR®. The dosage must have been stable for at least 3 months prior to screening. * Thiazolidinedione (TZD): pioglitazone \>/= 15 mg or rosiglitazone \>/= 24 mg. The subject must have been using the same thiazolidinedione for at least 6 months,and the dosage must have been stable for at least 3 months prior to screening. * HbA1c \>/= 8.0% * Fasting C-peptide concentration \> 0.27 nmol/L * Able and willing to perform self-monitoring of blood glucose (SMBG) up to 4 times a day * Able and willing to adhere to, and be compliant with, the study protocol * Able to read English or Spanish at the sixth-grade level in order to complete the subject reported outcomes component of the study * Signed informed consent and Health Insurance Portability and Accountability Act (HIPAA) authorization Exclusion Criteria: * Insulin use within the previous year * History of hypoglycemia unawareness * Acute or chronic, or history of, metabolic acidosis, including diabetic ketoacidosis * Impaired renal function as shown by, but not limited to, serum creatinine ≥ 3mg/dL. For subjects taking metformin, serum creatinine \>/= 1.5 mg/dL for males, or \>/= 1.4 mg/dL for females. * Serum alanine aminotransferase (ALT) or aspartate aminotransferase (AST) levels greater than 2.5 times the upper limit of normal (ULN) * Clinically significant peripheral edema if subject is using a TZD * History of stroke, myocardial infarction, coronary artery bypass graft, percutaneous transluminal coronary angioplasty, or angina pectoris, within the past 12 months * History of, or current, congestive heart failure (New York Heart Association \[NYHA\] III-IV) requiring pharmacologic treatment * Acute infection * Any malignancy within the past 5 years, with the exception of adequately treated basal or squamous cell carcinoma or adequately treated cervical carcinoma in situ * Current substance addiction or alcohol abuse or history of substance or alcohol abuse, within the past 2 years * Any clinically significant renal disease (other than proteinuria) or hepatic disease * Pregnant or lactating females * Dementia or mental condition rendering the subject unable to understand the nature, scope, and possible consequences of the study * Impaired dexterity or vision rendering the subject unable to administer injections * Known hypersensitivity to insulin glargine or insulin glulisine or any of the components of Lantus or Apidra * Any disease or condition (including abuse of illicit drugs, prescription medications, or alcohol) that, in the opinion of the investigator or sponsor, may interfere with the completion of the study * Unlikely to comply with the protocol, eg, uncooperative attitude, inability to return for follow-up visits, or unlikely to complete the study * Subject is the investigator or any sub-investigator, research assistant, pharmacist, study coordinator, other staff, or relative thereof, directly involved in the conduct of the protocol * No subject will be allowed to enroll in this study more than once.