Effect of Intravenous Ceftriaxone and Oral Doxycycline for Lyme Neuroborreliosis

Sorlandet Hospital HF120 enrolled

Overview

The aim of this study is to compare parenteral ceftriaxone and oral doxycycline in the treatment of neuroborreliosis in a randomized controlled trial.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

QUADRUPLE

Enrollment

120

Conditions

Lyme Neuroborreliosis

Interventions

CeftriaxoneDRUG

DoxycyclineDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Neurological symptoms and/or findings consistent with neuroborreliosis and at least one of the following fulfilled: * Intrathecal production of borrelia antibodies; * White cell count in cerebrospinal fluid (CSF) \> 5/mm3; * Significant rise in borrelia antibodies in two serum samples collected from a patient with at least 3 weeks interval; * Verified acrodermatitis chronica atrophicans. Exclusion Criteria: * Allergy to the contents in the medication, or earlier type I reaction to penicillin. * Treatment with cephalosporins, penicillin or tetracyclins during the last 14 days * Pregnancy or breastfeeding * Age \< 18 years

Locations (1)

Sørlandet Sykehus HF

Kristiansand, Vest-Agder, Norway

Data from ClinicalTrials.gov

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