Non-invasive Ways to Evaluate Lung Disease After Treatment With Xolair

Inclusion Criteria: * On medium to high dose inhaled corticosteroids either with or without a long acting beta agonist * Baseline IgE 30-700 IU/mL * Exhaled nitric oxide greater than 13 ppb * Positive skin test to at least one of the following perennial allergens: cat, dog, dust mite, cockroach * Stable asthma at the time of enrollment Exclusion Criteria: * Concurrent diseases/conditions, history of other diseases/conditions, with clinically significant uncontrolled systemic disease or a history of such disease (eg, infection, hematological, renal, hepatic, coronary heart disease or other cardiovascular disease, endocrinological, or gastrointestinal disease) within previous 3 months * Upper or lower respiratory tract infection within 6 weeks of screening visit * Elevated IgE level other than atopy * Known sensitivity to Xolair * \< 3 months of stable immunotherapy * Smokers * Pregnant/nursing women * Women of childbearing potential who are not practicing medically approved contraceptive methods (eg, oral, subcutaneous, mechanical, or surgical contraception) including abstinence * Patients who currently hav diagnosed cancer, are currently being investigated for possible cancer or who have any history of cancer * Known sensitivity to study drug or class of study drugs * Patients with severe medical condition(s) that in the view of the investigator prohibits participation in the study * Use of any other investigational agent in the last 30 days.