High Frequency Stimulation of the GPi or Thalamus in Tourette's Syndrome

Groupe Hospitalier Pitie-Salpetriere

Overview

Tourette's syndrome is a disabling neuropsychiatric disorder with major psychosocial consequences in some patients. The pathophysiology is still unknown. Some data suggest an dysfunction of limbic circuits in basal ganglia. The aim of this study is to evaluate the effect of high frequency stimulation of the internal part of the globus pallidus and/or parafascicular-median centre of the thalamus, two structures implicated in the limbic circuit, in patients with severe Tourette's syndrome.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Conditions

Tourette's Syndrome

Interventions

high frequency stimulationDEVICE

Eligibility

Sex: ALLMin age: 18 YearsMax age: 55 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Tourette's syndrome (DSM IV) * inducing a disability in the social and personal life * No improvement with medical treatment * Severe self suffering Exclusion Criteria: * Cognitive impairment (MMS \< 24) * Depression

Locations (1)

Centre d'Investigation Clinique-Hôpital Pitié-Salpetriere

Paris, France

Outcomes

Primary Outcomes

Severity of tics

Data from ClinicalTrials.gov

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