Ghrelin, Growth Hormone and Cortisol Interaction in Growth Hormone Deficient Patients

University of Aarhus8 enrolled

Overview

In growth hormone deficient patients: Determination of endogenous circulating ghrelin levels, ghrelin effects on insulin sensitivity, appetite, energy metabolism, and signal transduction in fat and muscle.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Hypopituitarism

Interventions

Human acylated ghrelinDRUG

5 pmol/kg body weight per min

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age between 18 and 60 yrs. * Verified hypopituitarism * Unchanged substitution treatment through 3+ months * Unchanged additional medical treatment * Oral and written informed consent Exclusion Criteria: * Age below 18 or above 60 yrs. * Diabetes mellitus * body mass index \> 30 * Fasting hypoglycemia * Convulsions * Allergy to trial products

Locations (1)

Aarhus University Hospital

Aarhus, Denmark

Outcomes

Primary Outcomes

Endogenous serum ghrelin levels

Time frame: Same day as intervention

Secondary Outcomes

Insulin sensitivity, appetite, metabolism, intracellular signal transduction

Time frame: Same day as intervention

Data from ClinicalTrials.gov

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