Foods containing more dairy fat (and thus a higher proportion of short and medium chain fatty acids and possibly some other nutrients or micronutrients with effect on energy intake, satiety or energy metabolism) affect energy balance and metabolic profile in subjects prone to develop abdominal adiposity and metabolic syndrome. The aim of the study is to test the hypothesis that intake of dairy products has a favorable effect on markers of the metabolic syndrome. To explore such a hypothesis the participants have to be in a free living situation during an extended study period.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
NONE
Enrollment
40
Lipidklinikken, Medisinsk avdeling, Rikshospitalet
Oslo, Norway
Weight
Body mass index (BMI)
Waist circumference/sagittal abdominal diameter
Proportion of body fat (bioelectrical impedance analysis [BIA], dual energy x-ray absorptiometry [DEXA])
Serum lipids (triglycerides [TG], cholesterol [chol], high-density lipoprotein [HDL] chol, low-density lipoprotein [LDL] chol, apolipoprotein (apo) B, apo A1, fatty acid composition)
Blood glucose, HbA1c%
Serum insulin, C-peptide
Blood pressure (systolic blood pressure [SBP], diastolic blood pressure [DBP])
Marker of fibrinolysis: plasminogen activator inhibitor [PAI-1]
Markers for inflammation: micro C-reactive protein (microCRP), interleukin-6 (IL-6), 15-keto-DH-prostaglandin F2 alfa (in urine), fibrinogen
Markers of endothelial function: vascular cell adhesion molecule (VCAM), vWillebrand factor
Lipid peroxidation ("oxidative stress"): 8-F2-isoprostanes (in urine)
Adiponectin, leptin
LDL particle size
Gene expression in leukocytes
Direct measurement of insulin sensitivity
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Glucose tolerance test (0, 30, 60, 90, 120)
Fat load test (0, 4, 6)
Serum free fatty acids (FFA)
Fat content of faeces
Polymorphisms in genes with direct influence on relation between endogen lipid synthesis and lipid oxidation (AMP-kinase, SREBP1c, stearoyl desaturase-SCD1, acetyl-CoA carboxylase-ACC2, acyl-CoA synthetase-ACS1)