The Renin-Angiotensin System in Essential Hypertension

St George's, University of London11 enrolled

Overview

Although ACE Inhibitors and Angiotensin Receptor Blockers are effective blood pressure lowering agents, the exact mechanisms by which these agents lower BP are still not fully understood. This study aims to compare the blood pressure and hormonal responses (plasma renin activity and aldosterone) to the ACE inhibitor enalapril and ARB candesartan in individuals with mild essential hypertension.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

NONE

Enrollment

Conditions

Hypertension

Interventions

Enalapril 20 mg bdDRUG

Candesartan 8 mg bdDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Essential Hypertension * SBP 140-159 mmHg * DBP 90-99 mmHg Exclusion Criteria: * Intolerance of or allergy to ACE Inhibitors or ARBS * Pregnant or Breastfeeding * Pre-menopausal women * Uncontrolled cardiac or renal failure * Diabetes mellitus

Locations (1)

Blood Pressure Unit, Dept. Cardiac & Vascular Sciences, SGUL

London, United Kingdom

Outcomes

Primary Outcomes

Change in BP

Change in PRA and aldosterone

Data from ClinicalTrials.gov

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