Tricaprilin in Mild to Moderate Alzheimer's Disease

Inclusion Criteria: * Informed Consent Form signed by patient and caregiver * Diagnosis of probably Alzheimer's disease of mild to moderate severity * Age 50 or older * If female, 2 years postmenopausal or surgically sterile * Hearing, vision, and physical abilities adequate to perform assessments (corrective aids allowed) * Caregiver to attend all visits, perform assessments, and supervise administration of study medication * CT or MRI within 24 months prior to screening compatible with a diagnosis of probably Alzheimer's disease * Modified Hachinski Ischemia Scale score of 4 or less * ADAS-Cog score between 15 and 35 inclusive at screening * MMSE score between 14 and 24 inclusive at screening * Stable medical condition for 3 consecutive months immediately prior to baseline * No clinically significant abnormal findings on the physical examination, medical history, or clinical laboratory results during screening Exclusion Criteria: * Any condition that would, in the opinion of the Principal Investigator, render the patient or the caregiver unsuitable for the study, or place them at substantial risk of adverse outcome * Unwillingness or inability of the patient and/or caregiver to fulfill the requirements of the study * Resident in a skilled nursing facility * Any significant neurological disease other than probable AD (e.g. Parkinson's disease, Huntington's disease, brain tumor, normal pressure hydrocephalus, progressive supranuclear palsy, seizure disorder, subdural hematoma, multiple sclerosis, history of stroke, or history of head injury requiring hospitalization) * An alternate cause for dementia other than AD as determined by a required CT or MRI scan within 24 months prior to screening * Current history of major psychiatric disorder * Major depression as determined by a Cornell Scale for Depression in Dementia * Clinically significant hypothyroidism * Clinically significant B12 deficiency * Unstable or clinically significant cardiovascular disease * Diabetes of any type * History of tertiary syphilis * Cancer within 3 years prior to baseline, with the exception of squamous and basal cell carcinoma * Vital sign abnormalities * Clinically significant renal disease or insufficiency * Clinically significant hepatic disease or insufficiency * Alcohol consumption greater than 2 oz of spirits per day or 14 oz per week (1 oz of spirits is equal to 6 oz of wine or 12 oz of beer) * Current history of alcohol abuse or other substance abuse within 24 months prior to baseline * Known HIV infection * Use of any investigational compound within 30 days prior to screening * Use of prohibited medications (contact site for details) * Prior or current use of medium-chain triglycerides (MCTs) for medical purposes * Known allergies to coconut oil