Amlodipine vs Nitrates Study in Patients With Chronic Stable Angina

Pfizer's Upjohn has merged with Mylan to form Viatris Inc.200 enrolled

Overview

The objective of study is to compare the anti-ischemic efficacy and safety profiles of once daily amlodipine or isosorbide-5-mononitrate in the treatment of stable asymptomatic and symptomatic myocardial ischemia

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

200

Conditions

Myocardial Ischemia

Interventions

AmlodipineDRUG

iso- 5 - mononitrateDRUG

Blood testsPROCEDURE

Exercise Stress TestPROCEDURE

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Outpatients \> =18 years of age with diagnosed clinically stable angina pectoris Exclusion Criteria: * Patients with congestive heart failure, clinically significant cardiovascular disease, standing systolic blood pressure of less than 100mmHg, concomitant anti-anginal therapies similar to sublingual NTG

Locations (12)

Pfizer Investigational Site

Athens, Attica, Greece

Pfizer Investigational Site

Athens, Greece

Pfizer Investigational Site

Athens, Greece

Outcomes

Primary Outcomes

Evaluate the time to 1mm ST depression

Secondary Outcomes

The number of patients experiencing angina attacks The frequency of hospitalizations due to angina attacks Time to onset of 1mm ST segment depression Total external workload performed Safety

Data from ClinicalTrials.gov

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