Rosiglitazone (Avandia®) Treatment in HIV: Its Effect on Blood Vessels

Inclusion Criteria: * HIV-positive * Between 30 and 70 years of age * Elevated blood levels of fat * On two or more anti-HIV drugs for at least12 months in a row and unlikely to change anti-HIV therapy during the study * On stable regimen for at least 6 months for women taking oral contraceptive agents or hormone replacement * On a stable regimen for at least 6 months for men on testosterone replacement * If taking nevirapine, on therapy for at least 3 months with stable liver function tests Exclusion Criteria: * Pregnancy and breastfeeding * Poorly controlled diabetes * Uncontrolled hypertension or clinical evidence of heart failure * Any serious medical conditions, including an active AIDS-defining condition, pancreatitis, or hepatitis within 6 months prior to the study * Laboratory abnormalities (see investigator) * On lipid lowering agents, insulin, anabolic steroids (except for testosterone at replacement doses), oral corticosteroids at greater than replacement doses, or growth hormones * History of liver reaction or severe edema associated with current thiazolidinedione * History of hypersensitivity to thiazolidinedione