The objectives of this study are to: * Evaluate the sensitivity and specificity of NT-proBNP (N-terminal prohormone brain natriuretic peptide) and new biomarker measurements for the diagnosis of heart failure in patients with acute dyspnea and/or edema. * Determine the exact biomarker cut-off point(s) for the differentiation of healthy persons, patients with heart failure and patients with dyspnea of other origin. * Evaluate treatment costs in patients with dyspnea under special consideration of NT-proBNP measurement.
Primary endpoint: * Sensitivity and specificity of biomarker measurements for discrimination of heart failure from dyspnea of other origin. Secondary endpoints: * Determination of Cut-off(s) * Discrimination of cardiac and non-cardiac diseases causing to dyspnea or peripheral edema * Determination of treatment costs of the initial hospital stay * Evaluation of resource savings when implementing NT-proBNP for determination of diagnosis. * Time to diagnosis. * Hospitalization rate /Intensive care treatment rate between day 1 and 28 * Duration of initial hospital stay * 30-day re-hospitalization rate * 30 day mortality rate and adverse event rate * 1 and 5 year mortality rates * 1 and 5 year rehospitalization rates
Study Type
OBSERVATIONAL
Enrollment
400
Medical Faculty Mannheim, University of Heidelberg
Mannheim, Baden-Wurttemberg, Germany
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