The antihypertensive effect of the increased dose of angiotensin II receptor blocker (AII antagonist) is compared with that of the additional combined use of amlodipine in hypertensive patients with Type 2 diabetes mellitus, who have been treated with AII antagonist, the antihypertensive effect of which has been inadequate.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
300
Dept. of Clinical Immunology, Clinical Bioinformatics Research Unit, Graduate School of Medicine, the University of Tokyo
Hongo, Bunkyo-ku, Tokyo, Japan
Changes in blood pressure level at home after getting up.
The rate of the blood pressure levels at home after getting up, which effected the target levels (systolic blood pressure < 125 mm Hg, diastolic blood pressure < 80 mm Hg).
Adverse events, adverse drug reactions
Clinical laboratory data
Changes in blood pressure levels measured on an outpatient basis.
The rate of the blood pressure levels measured on an outpatient basis, which effected the standard levels (systolic blood pressure level <130 mm Hg, diastolic blood pressure level < 80 mm Hg).
Changes in blood pressure levels measured at home before going to bed· Changes in IMT of the cervical artery
Changes in PWV· Changes in echocardiographic findings
Changes in urinary albumin level
Changes in BNP· Changes in hs-CRP· Medical cost-effectiveness
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