Safety And Anti-Inflammatory Effect Of SB681323 In Patients With Chronic Obstructive Pulmonary Disease (COPD)

Inclusion criteria: * Non-childbearing potential. * Clinical diagnosis of COPD. * Cigarette smoking history of greater than or equal to 10 pack years. * Post-bronchodilator FEV1 to FVC ratio (FEV1:FVC) \< 0.7 * Post-bronchodilator FEV1 50% - 80% of predicted normal. * Receiving inhaled corticosteroids for a minimum of 6 weeks prior to Screening. * Serum CRP concentration greater than 3mg/L. Exclusion criteria: * Current diagnosis of asthma. * Active tuberculosis, sarcoidosis or bronchiectasis. * History of any type of malignancy, rheumatoid arthritis or other conditions associated with chronic inflammation. * Clinically significant renal or hepatic disease. * History of increased liver function tests, or patients receiving hormone replacement therapy, statins or systemic or topical corticosteroids.